Radiopharmaceuticals

	10. INDIUM - 111 LABELLED CAPSULES  for investigation of colonic transit (Nottingham University Hospital)
	Formula:
	Propan - 2 - ol	as required
	Acetone BP	as required
	Alcohol BP (95%)	as required
	Ion exchange resin 50W x X8(H) (Dowex)	250 mg per dose
	Capsules No 2	1 per dose
	Eudragit x 100 (Eudragit)	as required
	Indium-111 chloride solution (INSIP) (Amersham Health)	4 MBq per dose
	Administered Dose	4 MBq
	Method
1.	Into a clean glass vial, weigh a quantity of ion exchange resin corresponding to 250 mg per dose required.
2.	Moisten the resin with a small volume of alcohol. Mix with a glass rod, and add a quantity of Indium-111 chloride solution corresponding to 5 MBq per dose required.
3.	Mix to distribute the indium activity evenly and dry under a gentle airstream.
4.	Fill No 2 gelatin capsules (fill weight approx 250 mg) with the dry radiolabelled resin.
5.	Close the capsules, trapping a length of fine braided silk suture between the capsule cap and body.
6.	Prepare a coating solution containing 13% Eudragit S100 in a mixture of propan-2-ol and acetone (60:40).
7.	Using the sutures to suspend the capsules, immerse in the coating solution for 30 seconds and allow to dry thoroughly for about 30 minutes. Repeat the procedure.
8.	When the capsules are thoroughly dry, assay for activity, and cut the sutures as close to the capsule body as possible.
9.	Measure and record the activity in each capsule and label appropriately.
	The capsules are now ready for administration. Capsules are administered with 150 ml water. Imaging is performed at 2 hours, 6 hours, 24 hours and at 24 hour intervals until activity is eliminated.
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