Radiopharmaceuticals

	13: CARBON - 14 UREA CAPSULES    for detection of Helicobacter pylori (City Hospital, Birmingham)
	Carbon-14 Urea (CFA 41)is purchased as a radiochemical from Amersham Pharmacia Biotech. It is not sold as a radiopharmaceutical and not covered by a UK Product Licence The material arrives as a freeze dried powder in a glass vial and has to be redissolved in Water for Injections prior to use
	Method
1.	To the freeze dried powder (Carbon-14 Urea 37 MBq) add 4.1 ml Water for Injection BP and mix thoroughly to achieve dissolution of the powder. Allow to stand for 1 hour to ensure this process is complete. The radioactive concentration of the solution will be approximately 90 kBq in 10 microlitres
2.	Fill the lower half of 100 empty gelatin capsules size 0 with lactose. The quantity will be approximately 400-500 mg per capsule
3.	To each capsule add 10 microlitres of the Carbon-14 Urea solution. Ensure the liquid is placed on to the lactose and not allowed to come into contact with the wall of the gelatin capsule
4.	Seal the capsules and transfer to a tablet bottle and label appropriately
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